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Enzyme Inhibition

The reduction in enzyme activity due to the presence of a substance, categorized as competitive, non-competitive, or uncompetitive.

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The statement of the theorem

For a general reversible enzyme-inhibitor interaction, the rate

v

under inhibition by

[I]

is modified from the standard Michaelis-Menten equation. For competitive inhibition, the apparent

K_m

is increased:\n

v = \frac{V_{max}[S]}{K_m(1 + \frac{[I]}{K_I}) + [S]}