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Wound Contraction

The physical reduction in wound size, primarily driven by the contraction of myofibroblasts. This mechanical process pulls the wound edges together, minimizing defect size.
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The statement of the theorem

Consider the wound area A(t)A(t) and the contractile stress σc\sigma_c. The rate of change of the wound area is governed by the contractile force exerted by myofibroblasts (Myo\text{Myo}) acting on the wound edges:\ndAdt=−2τ0EALdudt\frac{dA}{dt} = - \frac{2\tau_0}{E} \frac{A}{L} \frac{d\textbf{u}}{dt} \nwhere τ0\tau_0 is the maximum contractile stress, EE is the tissue elasticity modulus, LL is the wound length, and dudt\frac{d\textbf{u}}{dt} is the rate of displacement of the wound edges, which is proportional to the density of active myofibroblasts.