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Hypertrophic Scarring and Keloid Formation

Pathological overproduction and disorganized deposition of collagen. This is characterized by excessive myofibroblast activity and failure to properly degrade the provisional matrix.
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The statement of the theorem

Define the collagen deposition rate RcollR_{coll} and the degradation rate RdegR_{deg}. Pathological scarring is characterized by a positive feedback loop where excessive synthesis overwhelms degradation, leading to a runaway accumulation of matrix MM. \nd[M]dt=Rcoll−Rdeg=ksynth[Myo][TGF-β]−kMMP[MMP][M]\frac{d[M]}{dt} = R_{coll} - R_{deg} = k_{synth} [\text{Myo}] [\text{TGF-}\beta] - k_{MMP} [MMP] [M]\nPathological condition: ksynth[Myo][TGF-β]>kMMP[MMP][M]k_{synth} [\text{Myo}] [\text{TGF-}\beta] > k_{MMP} [MMP] [M] and a failure in the negative feedback mechanism that normally downregulates [TGF-β][\text{TGF-}\beta] and [Myo][\text{Myo}] after wound closure.
Source: Wikipedia